plumbing in the walls

[Hatter]

I live in the midwest - so I have cold winters. I am looking at plans for a house that has an open floor plan, so not many interior walls to run the plumbing(supply and drain). Is it possible to run the plumbing in the exterior walls if the insulation is done correctly? Or is that going to cause problems?
Thanks

[pushkins]

Insulated correctly then there should be no problems with the plumbing in the exterior walls.